Korea Treatment Guide

Rejuran in Korea

Rejuran is a PDRN skin booster, developed in South Korea, that uses salmon-derived polynucleotides to regenerate skin at the cellular level. Korea is the only market where all four variants (Healer, I, HB, S) have been in routine clinical use for over a decade, at 476+ Seoul clinics, from $300 per session.

Vera connects you with Rejuran clinics across Gangnam, Seocho, and Myeongdong, with transparent pricing and AI-powered treatment planning.

Download the App
Treatment typePDRN / PN Skin Booster
OriginDeveloped in South Korea by PharmaResearch Products (MFDS-approved)
Variants available in KoreaAll 4: Rejuran I (Eye), Healer (Full-Face), HB (Hydration), S (Scar)
Seoul clinics476+ across Gangnam, Seocho, Myeongdong (640+ Korea-wide)
Cost per session (Korea)$300 to $900 (vs. $500 to $1,200 in the US)
Sessions typical3 sessions, spaced 4 weeks apart. Maintenance every 6+ months
Results timelineTexture improvement at week 4. Peak results at 3 to 4 months
Pain level  2 / 5, topical numbing applied
DowntimeMinimal. 24 to 48 hours of pinpoint redness and small papules

Concerns

Dull Skin Fine Lines Acne Scars Dark Circles Dehydrated Skin Enlarged Pores Rough Texture Under-Eye Hollows

Treatment Areas

Face (full) Under Eyes Neck Hands

Why was Rejuran developed in Korea?

Rejuran is a Korean innovation. PharmaResearch Products, a South Korean biotech company, developed the PDRN (polydeoxyribonucleotide) skin booster and brought it to market through MFDS (Ministry of Food and Drug Safety, 식품의약품안전처) approval years before it became available anywhere else. Korean dermatologists were the first to refine injection protocols, dose calibrations, and combination strategies for PDRN.

The active compound is pharmaceutical-grade polynucleotide extracted from salmon DNA and extensively purified. When injected intradermally, PDRN is believed to support the skin's natural repair processes and collagen production, though the precise biological pathways in aesthetic use are still being studied. Unlike hyaluronic acid fillers that provide mechanical volume, Rejuran works biologically. It signals the skin to rebuild its own structural proteins.

What are the four Rejuran variants available in Korea?

Korean clinics stock all four Rejuran formulations. This is unusual. In the US and most other markets, only one or two variants are typically available. Walking into a Gangnam dermatology clinic means your provider can match (or combine) the exact formulation to your skin concerns in a single visit.

Rejuran I

Eye Specialist

Formulated for the delicate periorbital area. Ultra-fine PN fragments target dark circles, under-eye hollows, and fine crepe lines. The most common entry point for people new to Rejuran in Korean clinics.

Dark circles Under-eye fine lines Periorbital thinning

$300 to $900 · 3 sessions recommended

Rejuran Healer

Full-Face Regenerator

The original formulation. Injectable polynucleotide that signals cellular repair across the entire face, rebuilding skin density, elasticity, and collagen architecture. This is what Korean providers have been using since Rejuran first launched.

Overall skin quality Fine lines Collagen rebuilding

$400 to $900 · 3 sessions, 4 weeks apart

Rejuran HB

Hydration Booster

Combines PN with hyaluronic acid for dual-action regeneration and deep hydration. Korean providers often recommend HB for people who have flown in with jet-lagged, dehydrated skin and want immediate moisture along with long-term repair.

Dehydrated skin Dullness Moisture barrier

$400 to $800 · 3 sessions recommended

Rejuran S

Scar Revision

Higher-viscosity formulation for targeted scar treatment. Concentrated PN delivery directly into acne scars, surgical scars, and textural irregularities. Korean clinics often pair Rejuran S with laser or microneedling in the same session.

Acne scars Surgical scars Textural irregularities

$400 to $700 · Multiple sessions for scar revision

Vera

Find Vera Verified Providers

Vera's AI Aesthetician analyzes your skin profile and recommends the right Rejuran variant and Seoul clinics for your specific concerns.

Download the App

Why do people fly to Korea for Rejuran?

Korea is not just "a place that offers Rejuran." It is where the treatment was invented, where the clinical protocols were written, and where dermatologists have been injecting it in mainstream practice for over a decade. Korean providers have had 10+ years of MFDS-approved clinical experience with PDRN before most US clinics had even heard of it.

Cost matters, too. A full-face Rejuran Healer session in Seoul runs $300 to $900. The same treatment in the US costs $500 to $1,200 per session. A 3-session series in Korea can save you enough to cover the flights and still come out ahead, depending on your city of origin.

The Korean clinic experience is different from a US med spa. High volume, specialized, efficient. You walk into a Gangnam dermatology clinic, consult with the doctor, get numbed, and receive treatment in under 90 minutes. Many clinics see dozens of Rejuran people daily, which means technique is sharp and wait times are short.

What do Korean clinics combine with Rejuran?

Korean providers rarely do just one thing. Combination protocols are standard. You might walk in for Rejuran Healer and leave having also received Skin Botox for pore refinement or PRX-T33 for surface brightening. Common pairings include:

PRX-T33 Bio-Revitalization
Daxxify Neurotoxin
Alma Hybrid Laser Laser
ASCE+ Exosomes Regenerative
Skin Botox Neurotoxin
JetPeel Facial Treatment
Sylfirm X RF Microneedling
Juvelook Bio-Stimulator
Profhilo Bio-Remodeling
Candela Vbeam Vascular Laser

What does a Rejuran protocol look like in Korea?

A standard Rejuran protocol is 3 sessions spaced 4 weeks apart, with maintenance every 6+ months. If you are traveling to Seoul specifically for Rejuran, some people compress sessions 1 and 2 into a single trip (spaced 3 to 4 weeks), then complete session 3 back home or on a return visit.

  • Week 0 Consultation + first Rejuran session at your Seoul clinic
  • Week 4 Second session. Skin begins showing improved texture and density
  • Week 8 Third session. Collagen rebuilding accelerates noticeably
  • Month 3 to 4 Peak results visible: density, elasticity, overall skin quality
  • Month 6+ Maintenance session recommended to sustain results

What is the Rejuran experience like at a Korean clinic?

Korean aesthetic clinics move fast. The consultation-to-treatment pipeline is streamlined in a way that surprises people used to US med spas, where you might wait weeks between a consult and your first session. In Seoul, same-day treatment is standard.

  1. Walk in, consult: The doctor evaluates your skin and selects the Rejuran variant. Gangnam and Seocho clinics see dozens of Rejuran people daily. Most stock all four variants. No waiting period between consult and treatment.
  2. Numbing (20 to 30 minutes): EMLA cream is applied across the treatment area. Most Korean clinics include numbing at no additional charge. You wait in a treatment room, not a lobby.
  3. Injection (20 to 30 minutes): The provider injects Rejuran intradermally in a papule pattern, placing small raised blebs at 1 to 1.5cm intervals. A full-face treatment involves 50 to 100+ injection points. Experienced Korean injectors work quickly.
  4. Cool down and go: Ice packs are applied. You leave with visible small papules and mild redness that typically flatten within 2 to 4 hours and resolve within 24 to 48 hours. No extended recovery room time.
  5. Aftercare: Gentle cleanser and SPF for 24 hours. No retinoids, AHAs, or vigorous exercise for 24 to 48 hours. Most people are back to sightseeing by the next morning.

What do treatment plans say about Rejuran?

These descriptions reflect how providers commonly explain Rejuran to people considering the treatment.

"Salmon DNA fragments that signal cellular repair. Improves skin density and health around the eyes. Series of tiny injections; small bumps may appear briefly."

Provider recommendation

"Injectable PN (salmon DNA) that regenerates skin cells. Improves skin density, elasticity, and fine lines long-term. Involves a series of tiny injections across the face."

Provider recommendation

"A lightweight polynucleotide for the delicate under-eye skin. Improves dark circles and fine lines by healing skin. Tiny bumps at injection sites resolve within 1 to 2 days."

Provider recommendation

"Injections of purified salmon DNA to regenerate skin cells. Boosts collagen and repairs damage for improved skin health. Involves tiny papules at injection sites that fade quickly."

Provider recommendation

How does Rejuran pricing in Korea compare to the US?

Korean pricing reflects the density of competition. 476+ Seoul clinics offering Rejuran keeps prices significantly below Western markets. Gangnam and Seocho clinics are typically priced slightly higher than outer neighborhoods, but still well below US equivalents.

Variant Korea (Seoul) United States
Rejuran I (under eye) $300 to $900 $500 to $1,200
Rejuran Healer (full face) $400 to $900 $600 to $1,200
Rejuran HB (hydration) $400 to $800 $500 to $1,000
Rejuran S (scar) $400 to $700 $500 to $1,000

Prices are approximate ranges. 3 sessions typical for most variants. Many Korean clinics offer package pricing for a full series. Confirm pricing with your clinic before booking.

Compare real prices from Seoul clinics on the Vera app →

What do people ask about Rejuran in Korea?

Answers for people considering Rejuran treatment in Seoul.

What is Rejuran?

Rejuran is an injectable PDRN skin booster developed in South Korea. It uses salmon-derived polynucleotides to regenerate skin at the cellular level. Four variants exist: Rejuran Healer for full-face use, Rejuran I for under-eye concerns, Rejuran HB for hydration, and Rejuran S for scar revision. All four are routinely available at Korean clinics.

How much does Rejuran cost in Korea?

Rejuran costs $300 to $900 per session in Seoul, with 3 sessions being the standard protocol. 476+ Seoul clinics offer the treatment across Gangnam, Seocho, and Myeongdong. This is significantly lower than US pricing of $500 to $1,200 per session for the same formulations.

How many clinics in Seoul offer Rejuran?

More than 476 clinics in Seoul offer Rejuran, with 640+ across Korea and 2,464+ registered aesthetic institutions nationwide. Gangnam-gu and Seocho-gu have the highest concentration. Korean clinics typically stock all four Rejuran variants for same-day variant selection.

What treatments pair well with Rejuran in Korea?

Korean providers commonly combine Rejuran with complementary treatments. Common pairings include PRX-T33, Daxxify, Alma Hybrid Laser, ASCE+ Exosomes, and Skin Botox.

How long does it take to see Rejuran results?

Results develop over a 3-session protocol spaced 4 weeks apart. Texture improvement starts around week 4 after your first session. Peak results in density, elasticity, and skin quality appear at 3 to 4 months. Maintenance sessions every 6+ months sustain the collagen stimulation.

Researching Rejuran for your Seoul trip? Vera's AI Aesthetician analyzes your skin profile and recommends the right variant and clinics for your concerns.

Find Vera Verified Providers →
Your guide to science-backed beauty treatments.

Built by experts of clinical K-Beauty

4.6★  ·  25 ratings on the App Store

★★★★★

Cut through the noise

"Vera is the first app that actually helped me make sense of it all. It's like having a knowledgeable friend who's done all the homework. Game changer."

Mlymat · January 2026

Sources